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Treating obesity seriously: when recommendations for lifestyle change confront biological adaptations

Many clinicians are not adequately aware of the reasons that individuals with obesity struggle to achieve and maintain weight loss, and this poor awareness precludes the provision of effective intervention. Irrespective of starting weight, caloric restriction triggers several biological adaptations designed to prevent starvation. These adaptations might be potent enough to undermine the long-term effectiveness of lifestyle modification in most individuals with obesity, particularly in an environment that promotes energy overconsumption.

Read the full article here: http://www.thelancet.com/journals/landia/article/PIIS2213-8587(15)00009-1/fulltext

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